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Target
Neuronal acetylcholine receptor subunit alpha-4
Ligand
BDBM50252631
Substrate
n/a
Meas. Tech.
ChEMBL_492116 (CHEMBL947458)
IC50
900±n/a nM
Citation
 Tomizawa, M; Kagabu, S; Ohno, I; Durkin, KA; Casida, JE Potency and selectivity of trifluoroacetylimino and pyrazinoylimino nicotinic insecticides and their fit at a unique binding site niche. J Med Chem 51:4213-8 (2008) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-4
Synonyms:
ACHA4_CHICK | CHRNA4
Type:
PROTEIN
Mol. Mass.:
70849.36
Organism:
Gallus gallus
Description:
ChEMBL_492116
Residue:
622
Sequence:
MGFLVSKGNLLLLLCASIFPAFGHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPQEYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRIKWMPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLVSMHSHVDQLDYWESGEWVIINAVGNYNSKKYECCTEIYPDITYSFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSPRTHTMPDWVRRVFLDIVPRLLFMKRPSTVKDNCKKLIESMHKLTNSPRLWSETDMEPNFTTSSSPSPQSNEPSPTSSFCAHLEEPAKPMCKSPSGQYSMLHPEPPQVTCSSPKPSCHPLSDTQTTSISKGRSLSVQQMYSPNKTEEGSIRCRSRSIQYCYLQEDSSQTNGHSSASPASQRCHLNEEQPQHKPHQCKCKCRKGEAAGTPTQGSKSHSNKGEHLVLMSPALKLAVEGVHYIADHLRAEDADFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
  
Inhibitor
Name:
BDBM50252631
Synonyms:
CHEMBL494278 | N-(3-((6-chloropyridin-3-yl)methyl)thiazol-2(3H)-ylidene)pyrazine-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C14H10ClN5OS
Mol. Mass.:
331.78
SMILES:
Clc1ccc(Cn2ccs\c2=N/C(=O)c2cnccn2)cn1
Structure:
Search PDB for entries with ligand similarity: