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Target
Signal transducer and activator of transcription 3
Ligand
BDBM50252610
Substrate
n/a
Meas. Tech.
ChEMBL_487803 (CHEMBL1019235)
EC50
4600±n/a nM
Citation
 Xu, J; Cole, DC; Chang, CP; Ayyad, R; Asselin, M; Hao, W; Gibbons, J; Jelinsky, SA; Saraf, KA; Park, K Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. J Med Chem 51:4115-21 (2008) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3)
Type:
Protein
Mol. Mass.:
88064.31
Organism:
Homo sapiens (Human)
Description:
P40763
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
  
Inhibitor
Name:
BDBM50252610
Synonyms:
CHEMBL494257 | Ethyl 5,6,7,8-tetrafluoro-4-oxo-1-(pentafluorophenyl)-1,4-dihydroquinoline-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H6F9NO3
Mol. Mass.:
455.2308
SMILES:
CCOC(=O)c1cn(-c2c(F)c(F)c(F)c(F)c2F)c2c(F)c(F)c(F)c(F)c2c1=O |(2.69,3,;1.36,3.77,;.03,3,;-1.31,3.76,;-1.31,5.3,;-2.64,2.99,;-2.63,1.43,;-3.98,.65,;-3.97,-.88,;-2.64,-1.64,;-1.31,-.86,;-2.63,-3.17,;-1.29,-3.93,;-3.96,-3.96,;-3.96,-5.49,;-5.3,-3.19,;-6.63,-3.96,;-5.3,-1.65,;-6.65,-2.41,;-5.32,1.42,;-6.65,.66,;-6.66,-.88,;-7.99,1.43,;-9.32,.66,;-7.99,2.97,;-9.32,3.74,;-6.66,3.74,;-6.66,5.28,;-5.32,2.98,;-3.99,3.76,;-4,5.3,)|
Structure:
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