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Target
Signal transducer and activator of transcription 3
Ligand
BDBM50252660
Substrate
n/a
Meas. Tech.
ChEMBL_487803 (CHEMBL1019235)
EC50
130±n/a nM
Citation
 Xu, J; Cole, DC; Chang, CP; Ayyad, R; Asselin, M; Hao, W; Gibbons, J; Jelinsky, SA; Saraf, KA; Park, K Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters. J Med Chem 51:4115-21 (2008) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3)
Type:
Protein
Mol. Mass.:
88064.31
Organism:
Homo sapiens (Human)
Description:
P40763
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
  
Inhibitor
Name:
BDBM50252660
Synonyms:
Benzyl 1-(4-Cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate | CHEMBL493450
Type:
Small organic molecule
Emp. Form.:
C24H9F7N2O3
Mol. Mass.:
506.3287
SMILES:
Fc1cc2c(c(F)c1F)n(cc(C(=O)OCc1ccccc1)c2=O)-c1c(F)c(F)c(C#N)c(F)c1F |(-10.27,-12.39,;-8.94,-13.16,;-7.61,-12.39,;-6.28,-13.15,;-6.27,-14.71,;-7.61,-15.48,;-7.61,-17.02,;-8.94,-14.7,;-10.28,-15.47,;-4.93,-15.48,;-3.58,-14.7,;-3.59,-13.14,;-2.26,-12.37,;-2.26,-10.83,;-.92,-13.13,;.41,-12.36,;1.75,-13.13,;1.74,-14.66,;3.08,-15.43,;4.41,-14.65,;4.4,-13.11,;3.06,-12.35,;-4.94,-12.37,;-4.95,-10.83,;-4.92,-17.01,;-3.59,-17.77,;-2.26,-16.99,;-3.58,-19.31,;-2.24,-20.07,;-4.91,-20.09,;-4.91,-21.63,;-4.92,-23.16,;-6.25,-19.32,;-7.58,-20.09,;-6.25,-17.78,;-7.6,-18.54,)|
Structure:
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