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Target
Bone morphogenetic protein 4
Ligand
BDBM50262127
Substrate
n/a
Meas. Tech.
ChEMBL_490878 (CHEMBL989154)
IC50
350±n/a nM
Citation
 Cuny, GD; Yu, PB; Laha, JK; Xing, X; Liu, JF; Lai, CS; Deng, DY; Sachidanandan, C; Bloch, KD; Peterson, RT Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett 18:4388-92 (2008) [PubMed]  Article 
Target
Name:
Bone morphogenetic protein 4
Synonyms:
BMP2B | BMP4 | BMP4_HUMAN | DVR4
Type:
PROTEIN
Mol. Mass.:
46572.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1363193
Residue:
408
Sequence:
MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
  
Inhibitor
Name:
BDBM50262127
Synonyms:
7-chloro-4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | CHEMBL468399
Type:
Small organic molecule
Emp. Form.:
C25H21ClN6
Mol. Mass.:
440.927
SMILES:
Clc1ccc2c(ccnc2c1)-c1cnn2cc(cnc12)-c1ccc(cc1)N1CCNCC1
Structure:
Search PDB for entries with ligand similarity: