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Target
Bone morphogenetic protein 4
Ligand
BDBM50261976
Substrate
n/a
Meas. Tech.
ChEMBL_490878 (CHEMBL989154)
IC50
3300±n/a nM
Citation
 Cuny, GD; Yu, PB; Laha, JK; Xing, X; Liu, JF; Lai, CS; Deng, DY; Sachidanandan, C; Bloch, KD; Peterson, RT Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett 18:4388-92 (2008) [PubMed]  Article 
Target
Name:
Bone morphogenetic protein 4
Synonyms:
BMP2B | BMP4 | BMP4_HUMAN | DVR4
Type:
PROTEIN
Mol. Mass.:
46572.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1363193
Residue:
408
Sequence:
MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
  
Inhibitor
Name:
BDBM50261976
Synonyms:
3-(3-fluoropyridin-4-yl)-6-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)pyrazolo[1,5-a]pyrimidine | CHEMBL468003
Type:
Small organic molecule
Emp. Form.:
C24H25FN6O
Mol. Mass.:
432.4933
SMILES:
CN1CCN(CCOc2ccc(cc2)-c2cnc3c(cnn3c2)-c2ccncc2F)CC1
Structure:
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