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Target
Melatonin receptor type 1B
Ligand
BDBM50272621
Substrate
n/a
Meas. Tech.
ChEMBL_514504 (CHEMBL973546)
Ki
33.6±n/a nM
Citation
 Attia, MI; Witt-Enderby, PA; Julius, J Synthesis and pharmacological evaluation of pentacyclic 6a,7-dihydrodiindole and 2,3-dihydrodiindole derivatives as novel melatoninergic ligands. Bioorg Med Chem 16:7654-61 (2008) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1B
Synonyms:
MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2)
Type:
Enzyme
Mol. Mass.:
40203.54
Organism:
Homo sapiens (Human)
Description:
P49286
Residue:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
  
Inhibitor
Name:
BDBM50272621
Synonyms:
(+/-)-2-(2-Hydroxymethyl-5-methoxyindolin-1-ylmethyl)-melatonin | CHEMBL525374
Type:
Small organic molecule
Emp. Form.:
C24H29N3O4
Mol. Mass.:
423.5048
SMILES:
COc1ccc2N(Cc3[nH]c4ccc(OC)cc4c3CCNC(C)=O)C(CO)Cc2c1
Structure:
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