Reaction Details Report a problem with these data
Target
Cholecystokinin receptor type A
Ligand
BDBM50245180
Substrate
n/a
Meas. Tech.
ChEMBL_513421 (CHEMBL976508)
EC50
1.3±n/a nM
Citation
 Berger, R; Zhu, C; Hansen, AR; Harper, B; Chen, Z; Holt, TG; Hubert, J; Lee, SJ; Pan, J; Qian, S; Reitman, ML; Strack, AM; Weingarth, DT; Wolff, M; Macneil, DJ; Weber, AE; Edmondson, SD 2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity. Bioorg Med Chem Lett 18:4833-7 (2008) [PubMed]  Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCK-A receptor | CCK-AR | CCK1-R | CCKAR_MOUSE | Cckar | Cholecystokinin A receptor | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 receptor
Type:
PROTEIN
Mol. Mass.:
48454.29
Organism:
Mus musculus
Description:
ChEMBL_40042
Residue:
436
Sequence:
MDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSAVQILLYSFIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLIPGVVMVVAYGLISLELYQGIKFDASQKKSAKEKRLSSGGGGGGGSSSSRYEDSDGCYLQKSRPPRKLELQQLSTSSSGGRINRIRSSGSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPTGVRGEVGEEEDGRTIRASLSRYSYSHMSTSAPPH
  
Inhibitor
Name:
BDBM50245180
Synonyms:
3-(4-(1-(3-ethoxyphenyl)-2-p-tolyl-1H-imidazole-4-carbonyl)piperazin-1-yl)-1-naphthoic acid | CHEMBL505409 | CHEMBL505727
Type:
Small organic molecule
Emp. Form.:
C34H32N4O4
Mol. Mass.:
560.6423
SMILES:
CCOc1cccc(c1)-n1cc(nc1-c1ccc(C)cc1)C(=O)N1CCN(CC1)c1cc(C(O)=O)c2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: