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Target
Glucagon receptor
Ligand
BDBM50244509
Substrate
n/a
Meas. Tech.
ChEMBL_513211 (CHEMBL977341)
IC50
9±n/a nM
Citation
 Kodra, JT; Jørgensen, AS; Andersen, B; Behrens, C; Brand, CL; Christensen, IT; Guldbrandt, M; Jeppesen, CB; Knudsen, LB; Madsen, P; Nishimura, E; Sams, C; Sidelmann, UG; Pedersen, RA; Lynn, FC; Lau, J Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor. J Med Chem 51:5387-96 (2008) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50244509
Synonyms:
(R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3-methoxy-5-trifluoromethylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionicacid | CHEMBL456738
Type:
Small organic molecule
Emp. Form.:
C32H34F3N3O6
Mol. Mass.:
613.6241
SMILES:
COc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2CCCCC2)cc(c1)C(F)(F)F |r|
Structure:
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