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Target
Procathepsin L
Ligand
BDBM50244459
Substrate
n/a
Meas. Tech.
ChEMBL_513229 (CHEMBL977359)
IC50
>1000±n/a nM
Citation
 Teno, N; Masuya, K; Ehara, T; Kosaka, T; Miyake, T; Irie, O; Hitomi, Y; Matsuura, N; Umemura, I; Iwasaki, G; Fukaya, H; Toriyama, K; Uchiyama, N; Nonomura, K; Sugiyama, I; Kometani, M Effect of cathepsin K inhibitors on bone resorption. J Med Chem 51:5459-62 (2008) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50244459
Synonyms:
7-(2,2-dimethylpropyl)-6-[(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | CHEMBL528104
Type:
Small organic molecule
Emp. Form.:
C20H25N7O2
Mol. Mass.:
395.4582
SMILES:
CC(C)(C)Cn1c(CN2CCC3(CC2)NC(=O)NC3=O)cc2cnc(nc12)C#N
Structure:
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