Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50247044
Substrate
n/a
Meas. Tech.
ChEMBL_557759 (CHEMBL953268)
IC50
6000±n/a nM
Citation
 Shrestha, S; Bhattarai, BR; Kafle, B; Lee, KH; Cho, H Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity. Bioorg Med Chem 16:8643-52 (2008) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50247044
Synonyms:
5-((E)-2-{4-[(E)-2-(5-Bromo-3-carboxy-4-hydroxyphenyl)-vinyl]-3-methoxyphenyl}vinyl)-3-bromo-2-hydroxybenzoic acid | CHEMBL461734
Type:
Small organic molecule
Emp. Form.:
C25H18Br2O7
Mol. Mass.:
590.214
SMILES:
COc1cc(\C=C\c2cc(Br)c(O)c(c2)C(O)=O)ccc1\C=C\c1cc(Br)c(O)c(c1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: