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Target
Melanocortin receptor 4
Ligand
BDBM50253660
Substrate
n/a
Meas. Tech.
ChEMBL_538611 (CHEMBL1027401)
EC50
0.900000±n/a nM
Citation
 Tian, X; Switzer, AG; Derose, SA; Mishra, RK; Solinsky, MG; Mumin, RN; Ebetino, FH; Jayasinghe, LR; Webster, ME; Colson, AO; Crossdoersen, D; Pinney, BB; Farmer, JA; Dowty, ME; Obringer, CM; Cruze, CA; Burklow, ML; Suchanek, PM; Dong, L; Dirr, MK; Sheldon, RJ; Wos, JA Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents. J Med Chem 51:6055-66 (2008) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50253660
Synonyms:
2-{3-(2-Amino-ethyl-guanidino)-4-[2-amino-3-(4-fluoro-phenyl)-propionyl]-2-oxo-piperazin-1-yl}-N-methyl-3-naphthalen-2-yl-propionamide | CHEMBL443396
Type:
Small organic molecule
Emp. Form.:
C30H35FN8O3
Mol. Mass.:
574.6491
SMILES:
[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc2ccccc2c1)-[#7]-1-[#6]-[#6]-[#7](-[#6@@H](-[#6]-[#6]=[#7]\[#7]=[#6](\[#7])-[#7])-[#6]-1=O)-[#6](=O)-[#6@H](-[#7])-[#6]-c1ccc(F)cc1 |r,w:22.23|
Structure:
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