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Target
Adenosine receptor A1
Ligand
BDBM50253797
Substrate
n/a
Meas. Tech.
ChEMBL_538640 (CHEMBL1032277)
EC50
4300±n/a nM
Citation
 Ferguson, GN; Valant, C; Horne, J; Figler, H; Flynn, BL; Linden, J; Chalmers, DK; Sexton, PM; Christopoulos, A; Scammells, PJ 2-aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists. J Med Chem 51:6165-72 (2008) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50253797
Synonyms:
CHEMBL460366 | Ethyl 5-Amino-3-(4-methoxyphenyl)-4-oxo-3,4-dihydrothieno[3,4-d]pyridazine-1-carboxylate | cid_719449
Type:
Small organic molecule
Emp. Form.:
C16H15N3O4S
Mol. Mass.:
345.373
SMILES:
CCOC(=O)c1nn(-c2ccc(OC)cc2)c(=O)c2c(N)scc12
Structure:
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