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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50275549
Substrate
n/a
Meas. Tech.
ChEMBL_496886 (CHEMBL998555)
IC50
160±n/a nM
Citation
 Cheung, M; Harris, PA; Badiang, JG; Peckham, GE; Chamberlain, SD; Alberti, MJ; Jung, DK; Harris, SS; Bramson, NH; Epperly, AH; Stimpson, SA; Peel, MR The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors. Bioorg Med Chem Lett 18:5428-30 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50275549
Synonyms:
2-(4-fluorophenyl)-5-methyl-3-(pyridin-4-yl)pyrazolo[1,5-a]pyridine | CHEMBL524530
Type:
Small organic molecule
Emp. Form.:
C19H14FN3
Mol. Mass.:
303.333
SMILES:
Cc1ccn2nc(c(-c3ccncc3)c2c1)-c1ccc(F)cc1
Structure:
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