Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50232154
Substrate
n/a
Meas. Tech.
ChEMBL_492788 (CHEMBL939476)
Ki
0.6±n/a nM
Citation
 Moorjani, M; Luo, Z; Lin, E; Vong, BG; Chen, Y; Zhang, X; Rueter, JK; Gross, RS; Lanier, MC; Tellew, JE; Williams, JP; Lechner, SM; Malany, S; Santos, M; Crespo, MI; Díaz, JL; Saunders, J; Slee, DH 2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A(2A) antagonists with improved solubility and metabolic stability. Bioorg Med Chem Lett 18:5402-5 (2008) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50232154
Synonyms:
CHEMBL401321 | N-(2-(furan-2-yl)-6-(1H-pyrazol-1-yl)pyrimidin-4-yl)acetamide | N-(2-furan-2-yl-6-pyrazol-1-yl-pyrimidin-4-yl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C13H11N5O2
Mol. Mass.:
269.2587
SMILES:
CC(=O)Nc1cc(nc(n1)-c1ccco1)-n1cccn1
Structure:
Search PDB for entries with ligand similarity: