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Target
Glutamate racemase
Ligand
BDBM50246528
Substrate
n/a
Meas. Tech.
ChEMBL_558148 (CHEMBL959077)
pH
8±n/a
IC50
21000±n/a nM
Comments
extracted
Citation
 Breault, GA; Comita-Prevoir, J; Eyermann, CJ; Geng, B; Petrichko, R; Doig, P; Gorseth, E; Noonan, B Exploring 8-benzyl pteridine-6,7-diones as inhibitors of glutamate racemase (MurI) in gram-positive bacteria. Bioorg Med Chem Lett 18:6100-3 (2008) [PubMed]  Article 
Target
Name:
Glutamate racemase
Synonyms:
MURI_ENTFA | murI
Type:
PROTEIN
Mol. Mass.:
29478.43
Organism:
Enterococcus faecalis
Description:
ChEMBL_558148
Residue:
273
Sequence:
MSNQEAIGLIDSGVGGLTVLKEALKQLPNERLIYLGDTARCPYGPRPAEQVVQFTWEMADFLLKKRIKMLVIACNTATAVALEEIKAALPIPVVGVILPGARAAVKVTKNNKIGVIGTLGTIKSASYEIAIKSKAPTIEVTSLDCPKFVPIVESNQYRSSVAKKIVAETLQALQLKGLDTLILGCTHYPLLRPVIQNVMGSHVTLIDSGAETVGEVSMLLDYFDIAHTPEAPTQPHEFYTTGSAKMFEEIASSWLGIENLKAQQIHLGGNEND
  
Inhibitor
Name:
BDBM50246528
Synonyms:
4-amino-8-benzyl-2-(benzylthio)pteridine-6,7(5H,8H)-dione | CHEMBL462388
Type:
Small organic molecule
Emp. Form.:
C20H17N5O2S
Mol. Mass.:
391.446
SMILES:
Nc1nc(SCc2ccccc2)nc2n(Cc3ccccc3)c(=O)c(=O)[nH]c12
Structure:
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