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Target
D(2) dopamine receptor
Ligand
BDBM50273418
Substrate
n/a
Meas. Tech.
ChEMBL_561954 (CHEMBL1010017)
Ki
23.6±n/a nM
Citation
 Brown, DA; Kharkar, PS; Parrington, I; Reith, ME; Dutta, AK Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model. J Med Chem 51:7806-19 (2008) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50273418
Synonyms:
(+/-)-trans-4-(2-(4-Phenylpiperazin-1-yl)ethyl)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-7-ol | (-)-(4aS,10bS)-trans-4-(2-(4-Phenylpiperazin-1-yl)ethyl)-1,2,3,4,4a,5,6,10b-octa-hydrobenzo[f]quinolin-7-ol | CHEMBL516296
Type:
Small organic molecule
Emp. Form.:
C25H33N3O
Mol. Mass.:
391.549
SMILES:
Oc1cccc2[C@@H]3CCCN(CCN4CCN(CC4)c4ccccc4)[C@H]3CCc12 |r|
Structure:
Search PDB for entries with ligand similarity: