Reaction Details Report a problem with these data
Target
Arylamine N-acetyltransferase 1
Ligand
BDBM50274890
Substrate
n/a
Meas. Tech.
ChEMBL_494095 (CHEMBL942267)
IC50
1100±n/a nM
Citation
 Russell, AJ; Westwood, IM; Crawford, MH; Robinson, J; Kawamura, A; Redfield, C; Laurieri, N; Lowe, ED; Davies, SG; Sim, E Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2. Bioorg Med Chem 17:905-18 (2009) [PubMed]  Article 
Target
Name:
Arylamine N-acetyltransferase 1
Synonyms:
AAC1 | ARY1_HUMAN | NAT1
Type:
PROTEIN
Mol. Mass.:
33898.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1347886
Residue:
290
Sequence:
MDIEAYLERIGYKKSRNKLDLETLTDILQHQIRAVPFENLNIHCGDAMDLGLEAIFDQVVRRNRGGWCLQVNHLLYWALTTIGFETTMLGGYVYSTPAKKYSTGMIHLLLQVTIDGRNYIVDAGFGRSYQMWQPLELISGKDQPQVPCVFRLTEENGFWYLDQIRREQYIPNEEFLHSDLLEDSKYRKIYSFTLKPRTIEDFESMNTYLQTSPSSVFTSKSFCSLQTPDGVHCLVGFTLTHRRFNYKDNTDLIEFKTLSEEEIEKVLKNIFNISLQRKLVPKHGDRFFTI
  
Inhibitor
Name:
BDBM50274890
Synonyms:
(Z)-3-Amino-5-(4'-hydroxy-3',5-diiodobenzylidene)-2-thioxo-thiazolidin-4-one | CHEMBL511165
Type:
Small organic molecule
Emp. Form.:
C10H6I2N2O2S2
Mol. Mass.:
504.106
SMILES:
NN1C(=S)S\C(=C/c2cc(I)c(O)c(I)c2)C1=O
Structure:
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