Reaction Details Report a problem with these data
Target
Ribokinase
Ligand
BDBM50255788
Substrate
n/a
Meas. Tech.
ChEMBL_515843 (CHEMBL1030542)
IC50
>33000±n/a nM
Citation
 Desroy, N; Moreau, F; Briet, S; Le Fralliec, G; Floquet, S; Durant, L; Vongsouthi, V; Gerusz, V; Denis, A; Escaich, S Towards Gram-negative antivirulence drugs: new inhibitors of HldE kinase. Bioorg Med Chem 17:1276-89 (2009) [PubMed]  Article 
Target
Name:
Ribokinase
Synonyms:
RBSK_ECOLI | rbsK
Type:
PROTEIN
Mol. Mass.:
32281.04
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_515843
Residue:
309
Sequence:
MQNAGSLVVLGSINADHILNLQSFPTPGETVTGNHYQVAFGGKGANQAVAAGRSGANIAFIACTGDDSIGESVRQQLATDNIDITPVSVIKGESTGVALIFVNGEGENVIGIHAGANAALSPALVEAQRERIANASALLMQLESPLESVMAAAKIAHQNKTIVALNPAPARELPDELLALVDIITPNETEAEKLTGIRVENDEDAAKAAQVLHEKGIRTVLITLGSRGVWASVNGEGQRVPGFRVQAVDTIAAGDTFNGALITALLEEKPLPEAIRFAHAAAAIAVTRKGAQPSVPWREEIDAFLDRQR
  
Inhibitor
Name:
BDBM50255788
Synonyms:
((1,3-Benzothiazol-2-ylmethyl){[4-methyl-2-(2-naphthyl)-1,3-thiazol-5-yl]carbonyl}amino)acetic acid | CHEMBL479438
Type:
Small organic molecule
Emp. Form.:
C25H19N3O3S2
Mol. Mass.:
473.567
SMILES:
Cc1nc(sc1C(=O)N(CC(O)=O)Cc1nc2ccccc2s1)-c1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: