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Target
Sodium- and chloride-dependent taurine transporter
Ligand
BDBM50248652
Substrate
n/a
Meas. Tech.
ChEMBL_542994 (CHEMBL1018610)
IC50
>30000±n/a nM
Citation
 Zhao, Z; Leister, WH; O'Brien, JA; Lemaire, W; Williams, DL; Jacobson, MA; Sur, C; Kinney, GG; Pettibone, DJ; Tiller, PR; Smith, S; Hartman, GD; Lindsley, CW; Wolkenberg, SE Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors. Bioorg Med Chem Lett 19:1488-91 (2009) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent taurine transporter
Synonyms:
SC6A6_HUMAN | SLC6A6
Type:
PROTEIN
Mol. Mass.:
69833.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_543463
Residue:
620
Sequence:
MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPNRWAVEREGATPYNSRTVMNGALVKPTHIIVETMM
  
Inhibitor
Name:
BDBM50248652
Synonyms:
CHEMBL465129 | N-((4-(6-methoxypyridin-2-yl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamide
Type:
Small organic molecule
Emp. Form.:
C22H29N3O4S
Mol. Mass.:
431.548
SMILES:
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2)(CC1)c1cccc(OC)n1
Structure:
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