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Target
Sodium- and chloride-dependent taurine transporter
Ligand
BDBM50248059
Substrate
n/a
Meas. Tech.
ChEMBL_542994 (CHEMBL1018610)
IC50
>30000±n/a nM
Citation
 Zhao, Z; Leister, WH; O'Brien, JA; Lemaire, W; Williams, DL; Jacobson, MA; Sur, C; Kinney, GG; Pettibone, DJ; Tiller, PR; Smith, S; Hartman, GD; Lindsley, CW; Wolkenberg, SE Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors. Bioorg Med Chem Lett 19:1488-91 (2009) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent taurine transporter
Synonyms:
SC6A6_HUMAN | SLC6A6
Type:
PROTEIN
Mol. Mass.:
69833.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_543463
Residue:
620
Sequence:
MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPNRWAVEREGATPYNSRTVMNGALVKPTHIIVETMM
  
Inhibitor
Name:
BDBM50248059
Synonyms:
(S)-2-chloro-3,5-difluoro-N-(1-(1-(propylsulfonyl)-4-(pyridin-2-yl)piperidin-4-yl)ethyl)benzamide | CHEMBL517410
Type:
Small organic molecule
Emp. Form.:
C22H26ClF2N3O3S
Mol. Mass.:
485.975
SMILES:
CCCS(=O)(=O)N1CCC(CC1)([C@H](C)NC(=O)c1cc(F)cc(F)c1Cl)c1ccccn1 |r|
Structure:
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