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Target
Sodium- and chloride-dependent taurine transporter
Ligand
BDBM50248064
Substrate
n/a
Meas. Tech.
ChEMBL_543463 (CHEMBL1016011)
IC50
>30000±n/a nM
Citation
 Wolkenberg, SE; Zhao, Z; Wisnoski, DD; Leister, WH; O'Brien, J; Lemaire, W; Williams, DL; Jacobson, MA; Sur, C; Kinney, GG; Pettibone, DJ; Tiller, PR; Smith, S; Gibson, C; Ma, BK; Polsky-Fisher, SL; Lindsley, CW; Hartman, GD Discovery of GlyT1 inhibitors with improved pharmacokinetic properties. Bioorg Med Chem Lett 19:1492-5 (2009) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent taurine transporter
Synonyms:
SC6A6_HUMAN | SLC6A6
Type:
PROTEIN
Mol. Mass.:
69833.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_543463
Residue:
620
Sequence:
MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPNRWAVEREGATPYNSRTVMNGALVKPTHIIVETMM
  
Inhibitor
Name:
BDBM50248064
Synonyms:
2,4-dichloro-N-((4-(2-hydroxycyclohexyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamide | CHEMBL464417
Type:
Small organic molecule
Emp. Form.:
C22H32Cl2N2O4S
Mol. Mass.:
491.471
SMILES:
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC1)C1CCCCC1O
Structure:
Search PDB for entries with ligand similarity: