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Target
Glucose-6-phosphate 1-dehydrogenase
Ligand
BDBM50236240
Substrate
n/a
Meas. Tech.
ChEMBL_542430 (CHEMBL1010667)
Ki
460±n/a nM
Citation
 Cordeiro, AT; Thiemann, OH; Michels, PA Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites. Bioorg Med Chem 17:2483-9 (2009) [PubMed]  Article 
Target
Name:
Glucose-6-phosphate 1-dehydrogenase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
59057.43
Organism:
Trypanosoma brucei
Description:
ChEMBL_542430
Residue:
521
Sequence:
MQNCRKVADTLRKDSCDIIPDAAAPELKERALTIVVLGASGDLARNKTFPALFQLFCNGLIPRTINIVGYARTKMPDVEQWKKESLAKHFPRAKDRCPHIEAFLKTITYISGSYDGADDFFRLNDVITKFEESFPGKQKGGNRLFYLALPPSVFMHACTGIRTHVMQKPGLGWVRIIIEKPFGHDTESSNELSRQLEPLFEESQIFRIDHYLGKEMVQNIVVTRFANRVFSALWNNNNIACVRITFKESIGTEGRGGYFDKAGIIRDVVQNHLTQILSLLAMEKPRSLSPEDIRDEKVIVLRHVNPVTPADCVLGQYTRSEDGSIPGYLEDPTVPRGSKCATFVVLRLFINNDRWDGVPFIIEAGKAVERRYLGIRIQFKDEIRPFGVAAQRNELIIRAQPSEAMYLRLTAKTPGVLSDTHQTELDLSYEHRYNITLPDAYESLIHEALLGRSTNFVRKDELDAAWRIYTPLLEAIERGETTTYPYSAGSKGPAEAQKFVDDTGFKPLTGDIYQQRKLHHL
  
Inhibitor
Name:
BDBM50236240
Synonyms:
5alpha-androstan-3beta-OL-17-one | CHEMBL272195 | Epiandrosterone | epi-andosterone
Type:
Small organic molecule
Emp. Form.:
C19H30O2
Mol. Mass.:
290.4403
SMILES:
C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O |r|
Structure:
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