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Target
MO15-related protein kinase Pfmrk
Ligand
BDBM50194663
Substrate
n/a
Meas. Tech.
ChEMBL_564380 (CHEMBL962375)
IC50
22000±n/a nM
Citation
 Geyer, JA; Keenan, SM; Woodard, CL; Thompson, PA; Gerena, L; Nichols, DA; Gutteridge, CE; Waters, NC Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. Bioorg Med Chem Lett 19:1982-5 (2009) [PubMed]  Article 
Target
Name:
MO15-related protein kinase Pfmrk
Synonyms:
Protein kinase Pfmrk
Type:
PROTEIN
Mol. Mass.:
37992.30
Organism:
Plasmodium falciparum
Description:
ChEMBL_640752
Residue:
324
Sequence:
MENNSTERYIFKPNFLGEGSYGKVYKAYDTILKKEVAIKKMKLNEISNYIDDCGINFVLLREIKIMKEIKHKNIMSALDLYCEKDYINLVMEIMDYDLSKIINRKIFLTDSQKKCILLQILNGLNVLHKYYFMHRDLSPANIFINKKGEVKLADFGLCTKYGYDMYSDKLFRDKYKKNLNLTSKVVTLWYRAPELLLGSNKYNSSIDMWSFGCIFAELLLQKALFPGENEIDQLGKIFFLLGTPNENNWPEALCLPLYTEFTKATKKDFKTYFKIDDDDCIDLLTSFLKLNAHERISAEDAMKHRYFFNDPLPCDISQLPFNDL
  
Inhibitor
Name:
BDBM50194663
Synonyms:
(E)-1-Phenyl-3-pyridin-2-yl-propenone | 1-phenyl-3-(pyridin-2-yl)prop-2-en-1-one | CHEMBL16947 | WR-190433
Type:
Small organic molecule
Emp. Form.:
C14H11NO
Mol. Mass.:
209.2432
SMILES:
O=C(\C=C\c1ccccn1)c1ccccc1
Structure:
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