Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50256957
Substrate
n/a
Meas. Tech.
ChEMBL_566834 (CHEMBL957643)
EC50
2100±n/a nM
Citation
 Iino, T; Tsukahara, D; Kamata, K; Sasaki, K; Ohyama, S; Hosaka, H; Hasegawa, T; Chiba, M; Nagata, Y; Eiki, J; Nishimura, T Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators. Bioorg Med Chem 17:2733-43 (2009) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50256957
Synonyms:
3-Ethoxy-5-[2-(methylsulfonyl)phenoxy]-N-(4-methyl-1,3-thiazol-2-yl)benzamide | CHEMBL475229
Type:
Small organic molecule
Emp. Form.:
C20H20N2O5S2
Mol. Mass.:
432.513
SMILES:
CCOc1cc(Oc2ccccc2S(C)(=O)=O)cc(c1)C(=O)Nc1nc(C)cs1
Structure:
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