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Target
Acid-sensing ion channel 3
Ligand
BDBM50259583
Substrate
n/a
Meas. Tech.
ChEMBL_500746 (CHEMBL970525)
IC50
490±n/a nM
Citation
 Kuduk, SD; Di Marco, CN; Chang, RK; Dipardo, RM; Cook, SP; Cato, MJ; Jovanovska, A; Urban, MO; Leitl, M; Spencer, RH; Kane, SA; Bilodeau, MT; Hartman, GD; Bock, MG Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3). Bioorg Med Chem Lett 19:2514-8 (2009) [PubMed]  Article 
Target
Name:
Acid-sensing ion channel 3
Synonyms:
ACCN3 | ASIC3 | ASIC3_HUMAN | Amiloride-sensitive cation channel 3 | SLNAC1 | TNAC1
Type:
PROTEIN
Mol. Mass.:
58910.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_757561
Residue:
531
Sequence:
MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL
  
Inhibitor
Name:
BDBM50259583
Synonyms:
3-amino-5-(biphenyl-3-yl)-N-(diaminomethylene)pyrazine-2-carboxamide | CHEMBL513153
Type:
Small organic molecule
Emp. Form.:
C18H16N6O
Mol. Mass.:
332.3592
SMILES:
NC(=N)NC(=O)c1ncc(nc1N)-c1cccc(c1)-c1ccccc1
Structure:
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