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Target
Elongation of very long chain fatty acids protein 6
Ligand
BDBM50249764
Substrate
n/a
Meas. Tech.
ChEMBL_498144 (CHEMBL1007916)
IC50
123±n/a nM
Citation
 Takahashi, T; Nagase, T; Sasaki, T; Nagumo, A; Shimamura, K; Miyamoto, Y; Kitazawa, H; Kanesaka, M; Yoshimoto, R; Aragane, K; Tokita, S; Sato, N Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem 52:3142-5 (2009) [PubMed]  Article 
Target
Name:
Elongation of very long chain fatty acids protein 6
Synonyms:
ELOV6_HUMAN | ELOVL6 | FACE | LCE
Type:
PROTEIN
Mol. Mass.:
31392.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_572238
Residue:
265
Sequence:
MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMVYILMTKGLKQSVCDQGFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVVNYLVFCWMQHDQCHSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKMRKTTKAE
  
Inhibitor
Name:
BDBM50249764
Synonyms:
3'-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1'-phenyl-3'-(trifluoromethyl)-3',7'-dihydrospiro[cyclobutane-1,6'-indole]-2',4'(1'H,5'H)-dione | CHEMBL523990
Type:
Small organic molecule
Emp. Form.:
C28H24F3N3O3
Mol. Mass.:
507.5037
SMILES:
Cc1[nH]n(-c2ccccc2)c(=O)c1C1(C(=O)N(C2=C1C(=O)CC1(CCC1)C2)c1ccccc1)C(F)(F)F |c:19|
Structure:
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