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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50258692
Substrate
n/a
Meas. Tech.
ChEMBL_519763 (CHEMBL939026)
EC50
>30000±n/a nM
Citation
 Bridges, TM; Marlo, JE; Niswender, CM; Jones, CK; Jadhav, SB; Gentry, PR; Plumley, HC; Weaver, CD; Conn, PJ; Lindsley, CW Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem 52:3445-8 (2009) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50258692
Synonyms:
7-fluoro-1-(2-(trifluoromethyl)benzyl)indoline-2,3-dione | CHEMBL505038
Type:
Small organic molecule
Emp. Form.:
C16H9F4NO2
Mol. Mass.:
323.2418
SMILES:
Fc1cccc2C(=O)C(=O)N(Cc3ccccc3C(F)(F)F)c12
Structure:
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