Reaction Details Report a problem with these data
Target
Disintegrin and metalloproteinase domain-containing protein 10
Ligand
BDBM50269059
Substrate
n/a
Meas. Tech.
ChEMBL_523762 (CHEMBL1008370)
IC50
21±n/a nM
Citation
Burns, DM; Li, YL; Shi, E; He, C; Xu, M; Zhuo, J; Zhang, C; Qian, DQ; Li, Y; Wynn, R; Covington, MB; Katiyar, K; Marando, CA; Fridman, JS; Scherle, P; Friedman, S; Metcalf, B; Yao, W Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition. Bioorg Med Chem Lett 19:3525-30 (2009) [PubMed] Article
More Info.:
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 10
Synonyms:
ADA10_HUMAN | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) | KUZ | MADM
Type:
Enzyme
Mol. Mass.:
84160.93
Organism:
Homo sapiens (Human)
Description:
O14672
Residue:
748
Sequence:
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR
Inhibitor
Name:
BDBM50269059
Synonyms:
(1S,2S,5S)-N-hydroxy-2-(4-(3-isopropylphenyl)piperidine-1-carbonyl)-5-(2-oxo-2-(piperidin-1-yl)ethyl)cyclohexanecarboxamide | CHEMBL496829
Type:
Small organic molecule
Emp. Form.:
C29H43N3O4
Mol. Mass.:
497.6694
SMILES:
CC(C)c1cccc(c1)C1CCN(CC1)C(=O)[C@H]1CC[C@H](CC(=O)N2CCCCC2)C[C@@H]1C(=O)NO |r|