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Target
Tubulin--tyrosine ligase
Ligand
BDBM50293297
Substrate
n/a
Meas. Tech.
ChEMBL_519880 (CHEMBL961245)
Kd
3000±n/a nM
Citation
 Dal Piaz, F; Vassallo, A; Lepore, L; Tosco, A; Bader, A; De Tommasi, N Sesterterpenes as tubulin tyrosine ligase inhibitors. First insight of structure-activity relationships and discovery of new lead. J Med Chem 52:3814-28 (2009) [PubMed]  Article 
Target
Name:
Tubulin--tyrosine ligase
Synonyms:
TTL | TTL_HUMAN
Type:
PROTEIN
Mol. Mass.:
43213.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_519880
Residue:
377
Sequence:
MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLVQLVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIQPPISNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVHVIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFKEFNQYLTSALNITLESSILLQIKHIIRNCLLSVEPAISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFPPPDVEQPQTQPAAFIKL
  
Inhibitor
Name:
BDBM50293297
Synonyms:
6alpha,8alpha,15(S)-trihydroxy-23-carbossi-labd-13(14),17-dien-16(S),19-olide | CHEMBL497633
Type:
Small organic molecule
Emp. Form.:
C25H38O7
Mol. Mass.:
450.565
SMILES:
C\C(CC[C@H]1[C@](C)(O)C[C@H](O)[C@@H]2[C@]1(C)CCC[C@@]2(C)C(O)=O)=C/[C@H](O)[C@H]1OC(=O)C=C1C |r,c:31|
Structure:
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