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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50366682
Substrate
n/a
Meas. Tech.
ChEBML_204583
Ki
20±n/a nM
Citation
 Holt, DA; Levy, MA; Yen, HK; Oh, HJ; Metcalf, BW; Wier, PJ Inhibition of steroid 5α-reductase by 3-nitrosteroids: synthesis, mechanism of inhibition, and in vivo activity. Bioorg Med Chem Lett 1:27-32 (1991)    Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50366682
Synonyms:
CHEMBL1627395
Type:
Small organic molecule
Emp. Form.:
C26H37NO3
Mol. Mass.:
411.5769
SMILES:
CC(C)N(C(C)C)C(=O)[C@H]1CC[C@H]2[C@@H]3CCc4cc(ccc4[C@H]3CC[C@]12C)C(O)=O
Structure:
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