Reaction Details Report a problem with these data
Target
Thromboxane-A synthase
Ligand
BDBM50280065
Substrate
n/a
Meas. Tech.
ChEBML_209929
IC50
>10000±n/a nM
Citation
 Faull, AW; Gaskin, H; Hadfield, PS; Jessup, R; Russell, K; Watkins, WJ; Wayne, M Dual-acting thromboxane receptor antagonist/synthase inhibitors: heterocyclic variations Bioorg Med Chem Lett 2:1181-1186 (1992)    Article 
Target
Name:
Thromboxane-A synthase
Synonyms:
CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase
Type:
Enzyme
Mol. Mass.:
60524.67
Organism:
Homo sapiens (Human)
Description:
P24557
Residue:
533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
  
Inhibitor
Name:
BDBM50280065
Synonyms:
(Z)-6-((4S,5R)-2,2-Dimethyl-4-pyrazin-2-yl-[1,3]dioxan-5-yl)-hex-4-enoic acid | CHEMBL274942
Type:
Small organic molecule
Emp. Form.:
C16H22N2O4
Mol. Mass.:
306.3569
SMILES:
CC1(C)OC[C@@H](C\C=C/CCC(O)=O)[C@H](O1)c1cnccn1
Structure:
Search PDB for entries with ligand similarity: