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Target
Prothrombin
Ligand
BDBM50280655
Substrate
n/a
Meas. Tech.
ChEBML_210583
IC50
30±n/a nM
Citation
 Sall, DJ; Berry, DR; Coffman, WJ; Craft, TJ; Denney, ML; Gifford-Moore, DS; Kellam, ML; Smith, GF Characterization of LY806303 as a potent and selective inhibitor of thrombin Bioorg Med Chem Lett 2:1025-1028 (1992)    Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | THRB_BOVIN | Thrombin | Thrombin heavy chain | Thrombin light chain
Type:
Enzyme
Mol. Mass.:
70502.73
Organism:
Bos taurus (Bovine)
Description:
P00735
Residue:
625
Sequence:
MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS
  
Inhibitor
Name:
BDBM50280655
Synonyms:
3-Isobutyryloxy-benzo[4,5]thieno[3,2-b]furan-2-carboxylic acid methyl ester | CHEMBL268367
Type:
Small organic molecule
Emp. Form.:
C16H14O5S
Mol. Mass.:
318.344
SMILES:
COC(=O)c1oc2c(sc3ccccc23)c1OC(=O)C(C)C
Structure:
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