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Target
Neutrophil elastase
Ligand
BDBM50281087
Substrate
n/a
Meas. Tech.
ChEBML_63816
IC50
76000±n/a nM
Citation
 Adonias, M; Anayaba, J; Cámara, J; Canet, E; Gateau-Olesker, A; Gero, SD; Grande, M; Hernando, JI Enantioselective synthesis and antielastase activity of 1,3,4-trisubstituted and 3,4-disubstituted β-lactam antibiotics Bioorg Med Chem Lett 3:2547-2552 (1993)    Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50281087
Synonyms:
(3R,4S)-1-[(R)-[1,3]Dithian-2-yl-(2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-methyl]-3-methoxy-4-((E)-styryl)-azetidin-2-one | CHEMBL313838
Type:
Small organic molecule
Emp. Form.:
C27H37NO6S2
Mol. Mass.:
535.716
SMILES:
CO[C@@H]1[C@H](\C=C\c2ccccc2)N([C@H](C2OC(C)(C)OC2C2COC(C)(C)O2)C2SCCCS2)C1=O
Structure:
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