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Target
Cathepsin G
Ligand
BDBM50281589
Substrate
n/a
Meas. Tech.
ChEBML_45365
Ki
2200±n/a nM
Citation
 Angelastro, MR; Bey, P; Mehdi, S; Janusz, MJ; Peet, NP Janus compounds: dual inhibitors of proteinases Bioorg Med Chem Lett 3:525-530 (1993)    Article 
Target
Name:
Cathepsin G
Synonyms:
CATG_HUMAN | CG | CTSG
Type:
PROTEIN
Mol. Mass.:
28860.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469016
Residue:
255
Sequence:
MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL
  
Inhibitor
Name:
BDBM50281589
Synonyms:
5N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)-1-[3-methyl-2-{4-[2-methyl-1-[5-(3,3,4,4,4-pentafluoro-1-isopropyl-2-oxobutylcarbamoyl)-(5S)-dihydro-1H-1-pyrrolylcarbonyl]-(1S)-propylcarbamoyl]phenylcarboxamido}-(2R)-butanoyl]-(5R)-dihydro-1 | CHEMBL422675
Type:
Small organic molecule
Emp. Form.:
C45H54F8N6O8
Mol. Mass.:
958.9329
SMILES:
CC(C)[C@@H](NC(=O)c1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NC(C(C)C)C(=O)C(F)(F)C(F)(F)F)C(=O)N1CCC[C@@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)F
Structure:
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