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Target
D(4) dopamine receptor
Ligand
BDBM50284083
Substrate
n/a
Meas. Tech.
ChEMBL_58939 (CHEMBL671253)
Ki
621±n/a nM
Citation
 Haadsma-Svensson, SR; Smith, MW; Lin, CH; Duncan, JN; Sonesson, C; Wikström, H; Waters, N; Carlsson, A; Svensson, K Synthesis and biological activity of C-5 modified derivatives of (+)-AJ76 and (+)-UH232: Increased dopamine D3 receptor preference and improved pharmacokinetic properties Bioorg Med Chem Lett 4:689-694 (1994)    Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50284083
Synonyms:
CHEMBL349843 | Trifluoro-methanesulfonic acid (5S,6R)-5-methyl-6-propylamino-5,6,7,8-tetrahydro-naphthalen-1-yl ester
Type:
Small organic molecule
Emp. Form.:
C15H20F3NO3S
Mol. Mass.:
351.384
SMILES:
CCCN[C@@H]1CCc2c(OS(=O)(=O)C(F)(F)F)cccc2[C@@H]1C
Structure:
Search PDB for entries with ligand similarity: