Reaction Details Report a problem with these data
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50421737
Substrate
n/a
Meas. Tech.
ChEBML_204581
IC50
>430±n/a nM
Citation
 McDonald, IA; Nyce, PL; Muench, DM; Gates, CA; Blohm, TR; Laughlin, ME; Weintruab, PM Inhibition of steroid 5α-reductase by “inverted”, competitive inhibitors Bioorg Med Chem Lett 4:847-851 (1994)    Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50421737
Synonyms:
CHEMBL2311174
Type:
Small organic molecule
Emp. Form.:
C19H31NO2
Mol. Mass.:
305.4549
SMILES:
CN1C2CC[C@H]3[C@@H]4CC[C@H](O)[C@@]4(C)CC[C@@H]3[C@@]2(C)CCC1=O
Structure:
Search PDB for entries with ligand similarity: