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Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM50284291
Substrate
n/a
Meas. Tech.
ChEMBL_66286 (CHEMBL678155)
IC50
16000±n/a nM
Citation
 Wang, GT; Lane, B; Fesik, SW; Petros, A; Luly, J; Krafft, GA Synthesis and FKBP binding of small molecule mimics of the tricarbonyl region of FK506 Bioorg Med Chem Lett 4:1161-1166 (1994)    Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM50284291
Synonyms:
(S)-1-[2-Oxo-2-(3,4,5-trimethoxy-phenyl)-acetyl]-piperidine-2-carboxylic acid 4-(4-methoxy-phenyl)-butyl ester | CHEMBL16722
Type:
Small organic molecule
Emp. Form.:
C28H35NO8
Mol. Mass.:
513.5794
SMILES:
COc1ccc(CCCCOC(=O)[C@@H]2CCCCN2C(=O)C(=O)c2cc(OC)c(OC)c(OC)c2)cc1
Structure:
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