Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50284867
Substrate
n/a
Meas. Tech.
ChEBML_54063
Ki
11±n/a nM
Citation
 Batt, DG; Copeland, RA; Dowling, RL; Gardner, TL; Jones, EA; Orwat, MJ; Pinto, DJ; Pitts, WJ; Magolda, RL; Jaffee, BD Immunosuppressive structure-activity relationships of Brequinar and related cinchoninic acid derivatives Bioorg Med Chem Lett 5:1549-1554 (1995)    Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50284867
Synonyms:
CHEMBL43639 | Sodium; 6-fluoro-2-(2'-fluoro-4'-hydroxy-biphenyl-4-yl)-3-methyl-quinoline-4-carboxylate
Type:
Small organic molecule
Emp. Form.:
C23H14F2NO3
Mol. Mass.:
390.3595
SMILES:
Cc1c(nc2ccc(F)cc2c1C([O-])=O)-c1ccc(cc1)-c1ccc(O)cc1F
Structure:
Search PDB for entries with ligand similarity: