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Target
Oxytocin receptor
Ligand
BDBM50285308
Substrate
n/a
Meas. Tech.
ChEMBL_149058 (CHEMBL761411)
IC50
7±n/a nM
Citation
 Hobbs, DW; Gould, NP; Hoffman, JB; Clineschmidt, BV; Pettibone, DJ; Veber, DF; Freidinger, RM Non-peptide oxytocin antagonists: identification and synthesis of a potent camphor aminosuccinimide Bioorg Med Chem Lett 5:119-122 (1995)    Article 
Target
Name:
Oxytocin receptor
Synonyms:
OT-R | OXYR_RAT | Otr | Oxtr | Oxytocin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42889.28
Organism:
RAT
Description:
Oxytocin OXTR RAT::P70536
Residue:
388
Sequence:
MEGTPAANWSVELDLGSGVPPGEEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLGTWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAAEGNDAAGGAGRAALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDVNAPKEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFFCCSARYLKGSRPGETSVSKKSNSSTFVLSRRSSSQRSCSQPSSA
  
Inhibitor
Name:
BDBM50285308
Synonyms:
3-amino-1-[7,7-dimethyl-1-spiro[2,3-dihydro-1H-indene-1,4'-(hexahydropyridine)]-1-ylsulfonylmethyl-(1S,2S)-bicyclo[2.2.1]hept-2-yl]-(3S)-tetrahydro-1H-2,5-pyrroledione | CHEMBL19658
Type:
Small organic molecule
Emp. Form.:
C27H37N3O4S
Mol. Mass.:
499.665
SMILES:
CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc34)CC1)[C@H](C2)N1C(=O)C[C@H](N)C1=O |THB:27:25:1:5.4|
Structure:
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