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Target
Neutrophil elastase
Ligand
BDBM50286321
Substrate
n/a
Meas. Tech.
ChEBML_86691
Ki
1±n/a nM
Citation
 Subramanyam, C; Bell, MR; Ghose, AK; Kumar, V; Dunlap, RP; Franke, C; Mura, AJ Inhibitors of human leukocyte elastase. 3.1 inhibition by tetrahydrobenzisothiazolinylmethyl aryl carboxylates Bioorg Med Chem Lett 5:325-330 (1995)    Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50286321
Synonyms:
2,6-Dichloro-benzoic acid 4,4-dimethyl-1,1,3-trioxo-1,3,4,5,6,7-hexahydro-1lambda*6*-benzo[d]isothiazol-2-ylmethyl ester | CHEMBL114017
Type:
Small organic molecule
Emp. Form.:
C17H17Cl2NO5S
Mol. Mass.:
418.292
SMILES:
CC1(C)CCCC2=C1C(=O)N(COC(=O)c1c(Cl)cccc1Cl)S2(=O)=O |c:6|
Structure:
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