Reaction Details Report a problem with these data
Target
Leukotriene B4 receptor 1
Ligand
BDBM50286746
Substrate
n/a
Meas. Tech.
ChEBML_99655
Ki
38000±n/a nM
Citation
 Masamune, H; Breslow, R; Cheng, JB; Conklyn, MJ; Eggler, JF; Marfat, A; Melvin, LS; Pillar, JS; Shirley, JT; Showell, HJ; Tickner, JE Synthesis and in vitro profile of 7-substituted quinoline chromanols as novel, non-acidic LTB4 antagonists Bioorg Med Chem Lett 5:887-892 (1995)    Article 
Target
Name:
Leukotriene B4 receptor 1
Synonyms:
BLT | BLT1 | BLTR | CMKRL1 | Chemoattractant receptor-like 1 | G-protein coupled receptor 16 | GPR16 | LT4R1_HUMAN | LTB4-R 1 | LTB4R | Leukotriene B4 R1 | Leukotriene B4 receptor | Leukotriene B4 receptor 1 | P2RY7 | P2Y purinoceptor 7 | P2Y7
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37582.68
Organism:
Homo sapiens (Human)
Description:
Q15722
Residue:
352
Sequence:
MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
  
Inhibitor
Name:
BDBM50286746
Synonyms:
(3S,4S)-3-Pyridin-3-ylmethyl-7-(quinolin-2-ylmethoxy)-chroman-4-ol | CHEMBL169743
Type:
Small organic molecule
Emp. Form.:
C25H22N2O3
Mol. Mass.:
398.4538
SMILES:
O[C@H]1[C@@H](Cc2cccnc2)COc2cc(OCc3ccc4ccccc4n3)ccc12
Structure:
Search PDB for entries with ligand similarity: