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Target
Endothelin-1 receptor
Ligand
BDBM50287200
Substrate
n/a
Meas. Tech.
ChEBML_225759
IC50
2±n/a nM
Citation
 Bunker, AM; Edmunds, JJ; Berryman, KA; Walker, DM; Flynn, MA; Welch, KM; Doherty, AM 1-benzyl-3-thioaryl-2-carboxyindoles as potent non-peptide endothelin antagonists Bioorg Med Chem Lett 6:1367-1370 (1996)    Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50287200
Synonyms:
1-Benzo[1,3]dioxol-5-ylmethyl-5,6-dimethoxy-3-(3,4,5-trimethoxy-phenylsulfanyl)-1H-indole-2-carboxylic acid | CHEMBL287169
Type:
Small organic molecule
Emp. Form.:
C28H27NO9S
Mol. Mass.:
553.58
SMILES:
COc1cc(Sc2c(C(O)=O)n(Cc3ccc4OCOc4c3)c3cc(OC)c(OC)cc23)cc(OC)c1OC
Structure:
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