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Target
Endothelin-1 receptor
Ligand
BDBM50287191
Substrate
n/a
Meas. Tech.
ChEBML_225759
IC50
170±n/a nM
Citation
 Bunker, AM; Edmunds, JJ; Berryman, KA; Walker, DM; Flynn, MA; Welch, KM; Doherty, AM 1-benzyl-3-thioaryl-2-carboxyindoles as potent non-peptide endothelin antagonists Bioorg Med Chem Lett 6:1367-1370 (1996)    Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50287191
Synonyms:
7-(3,4-Dimethoxy-phenylsulfanyl)-5-(7-methoxy-benzo[1,3]dioxol-5-ylmethyl)-5H-[1,3]dioxolo[4,5-f]indole-6-carboxylic acid | CHEMBL283858
Type:
Small organic molecule
Emp. Form.:
C27H23NO9S
Mol. Mass.:
537.538
SMILES:
COc1cc(Cn2c(C(O)=O)c(Sc3ccc(OC)c(OC)c3)c3cc4OCOc4cc23)cc2OCOc12
Structure:
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