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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50288393
Substrate
n/a
Meas. Tech.
ChEBML_159273
IC50
>1000000±n/a nM
Citation
 Pinto, DJ; Copeland, RA; Covington, MB; Pitts, WJ; Batt, DG; Orwat, MJ; Lam, GN; Joshi, A; Chan, YC; Wang, S; Trzaskos, JM; Magolda, RL; Kornhauser, DM Chemistry and pharmacokinetics of diarylthiophenes and terphenyls as selective COX-2 inhibitors Bioorg Med Chem Lett 6:2907-2912 (1996)    Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Protein
Mol. Mass.:
68868.60
Organism:
Ovis aries (Sheep)
Description:
n/a
Residue:
600
Sequence:
MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRRFLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
  
Inhibitor
Name:
BDBM50288393
Synonyms:
2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-5-nitro-thiophene | CHEMBL317606
Type:
Small organic molecule
Emp. Form.:
C17H12FNO4S2
Mol. Mass.:
377.41
SMILES:
CS(=O)(=O)c1ccc(cc1)-c1cc(sc1-c1ccc(F)cc1)[N+]([O-])=O
Structure:
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