Reaction Details Report a problem with these data
Target
Endothelin-1 receptor
Ligand
BDBM50288536
Substrate
n/a
Meas. Tech.
ChEBML_63190
IC50
8500±n/a nM
Citation
 Cheng, XM; Lee, C; Klutchko, S; Winters, T; Reynolds, EE; Welch, KM; Flynn, MA; Doherty, AM Synthesis and structure-activity relationships of 9-substituted acridines as endothelin-A receptor antagonists Bioorg Med Chem Lett 6:2999-3002 (1996)    Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50288536
Synonyms:
2-Acridin-9-yl-2-benzo[1,3]dioxol-5-yl-acetamide | CHEMBL100120
Type:
Small organic molecule
Emp. Form.:
C22H16N2O3
Mol. Mass.:
356.374
SMILES:
NC(=O)C(c1ccc2OCOc2c1)c1c2ccccc2nc2ccccc12
Structure:
Search PDB for entries with ligand similarity: