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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50289092
Substrate
n/a
Meas. Tech.
ChEBML_159270
IC50
>10000±n/a nM
Citation
 Leblanc, Y; Black, WC; Chan, CC; Charleson, S; Delorme, D; Denis, D; Gauthier, JY; Grimm, EL; Gordon, R; Guay, D; Hamel, P; Kargman, S; Lau, CK; Mancini, J; Ouellet, M; Percival, D; Roy, P; Skorey, K; Tagari, P; Vickers, P Synthesis and biological evaluation of both enantiomers of L-761,000 as inhibitors of cyclooxygenase 1 and 2 Bioorg Med Chem Lett 6:731-736 (1996)    Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
Cox-1 | Cox1 | Cyclooxygenase | Cyclooxygenase-1 | PGH1_RAT | Prostaglandin G/H synthase (cyclooxygenase) | Ptgs1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
69033.56
Organism:
RAT
Description:
COX-1 0 RAT::Q63921
Residue:
602
Sequence:
MSRRSLSLQFPLLLLLLLLPPPPVLLTDAGVPSPVNPCCYYPCQNQGVCVRFGLDHYQCDCTRTGYSGPNCTIPEIWTWLRSSLRPSPSFTHFLLTHGYWIWEFVNATFIREVLMRLVITVRSNLIPSPPTYNTAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDIHLLAQRLLLRREFIPGPQGTNVLFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDSLERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPEKQMAVGQEVFGLLPGLMLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIIIEEYVQHLSGYFLQLKFDPELLFRAQFQYRNRIALEFNHLYHWHPLMPDSFQVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQRAGRIGGGRNFDYHVLHVAEDVIKESREMRLQSFNEYRKRFGLKPYTSFQEFTGEKEMAAELEELYGDIDALEFYPGLMLEKCQPNSLFGESMIEMGAPFSLKGLLGNPICSPEYWKPSTFGGDVGFNIVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVFVRPSTEL
  
Inhibitor
Name:
BDBM50289092
Synonyms:
(R)-4-[1-(4-Bromo-benzyl)-5-methoxy-2-methyl-1H-indol-3-yl]-3-methyl-butyric acid | CHEMBL348945 | L-761066
Type:
Small organic molecule
Emp. Form.:
C22H24BrNO3
Mol. Mass.:
430.335
SMILES:
COc1ccc2n(Cc3ccc(Br)cc3)c(C)c(C[C@@H](C)CC(O)=O)c2c1
Structure:
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