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Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM50289142
Substrate
n/a
Meas. Tech.
ChEBML_210838
Ki
30±n/a nM
Citation
 Madge, DJ; Hazelwood, R; Iyer, R; Jones, HT; Salter, M Novel tryptophan dioxygenase inhibitors and combined tryptophan dioxygenase/5-HT reuptake inhibitors Bioorg Med Chem Lett 6:857-860 (1996)    Article 
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
T23O_RAT | TO | TRPO | Tdo | Tdo2 | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase
Type:
PROTEIN
Mol. Mass.:
47856.01
Organism:
Rattus norvegicus
Description:
ChEMBL_210838
Residue:
406
Sequence:
MSGCPFSGNSVGYTLKNLSMEDNEEDGAQTGVNRASKGGLIYGDYLQLEKILNAQELQSEIKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVMTRMHRVVVIFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHYRDNFEGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPHGFNFWGKFEKNILKGLEEEFLKIQAKKDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGSKAGTGGSSGYYYLRSTVSDRYKVFVDLFNLSSYLVPRHWIPKMNPIIHKFLYTAEYSDSSYFSSDESD
  
Inhibitor
Name:
BDBM50289142
Synonyms:
3-((E)-2-Pyridin-4-yl-vinyl)-1H-indole | CHEMBL166509
Type:
Small organic molecule
Emp. Form.:
C15H12N2
Mol. Mass.:
220.2692
SMILES:
C(=C/c1ccncc1)\c1c[nH]c2ccccc12
Structure:
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