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Target
Prolyl endopeptidase
Ligand
BDBM50240498
Substrate
n/a
Meas. Tech.
ChEBML_157480
IC50
20±n/a nM
Citation
 Károly, K; Sándor, Es; Edit, S; Miklós, F; Judit, S; Benjámin, P; Andrea, S; István, H Prolyl endopeptidase inhibitors1: N-acyl derivatives of L-thioproline-pyrrolidine Bioorg Med Chem Lett 7:1701-1704 (1997)    Article 
Target
Name:
Prolyl endopeptidase
Synonyms:
PPCE_RAT | Prep
Type:
PROTEIN
Mol. Mass.:
80731.99
Organism:
Rattus norvegicus
Description:
ChEMBL_1336163
Residue:
710
Sequence:
MLSFQYPDVYRDETSVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNTLSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFTCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLCYHVLGTDQSEDVLCAEFPDEPKWMGGAELSDDGRYVLLSIWEGCDPVNRLWYCDLQQGSNGINGILKWVKLIDNFEGEYDYITNEGTVFTFKTNRNSPNYRLINIDFTDPDESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLRNVKNILQLHDLTTGALLKTFPLDVGSVVGYSGRKKDSEIFYQFTSFLSPGVIYHCDLTREELEPRVFREVTVKGIDASDYQTIQVFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTTSKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKFTIGHAWTTDYGCSDSKQHFEWLLKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGPGKPTAKVIEEVSDMFAFIARCLNIEWIQ
  
Inhibitor
Name:
BDBM50240498
Synonyms:
(S)-1-(2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl)octan-1-one | 1-[(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidin-1-yl]-octan-1-one | CHEMBL298028
Type:
Small organic molecule
Emp. Form.:
C17H30N2O2
Mol. Mass.:
294.4323
SMILES:
CCCCCCCC(=O)N1CCC[C@H]1C(=O)N1CCCC1 |r|
Structure:
Search PDB for entries with ligand similarity: