Reaction Details Report a problem with these data
Target
Substance-P receptor
Ligand
BDBM50346332
Substrate
n/a
Meas. Tech.
ChEMBL_143040 (CHEMBL750289)
Ki
10±n/a nM
Citation
 Armour, DR; Aston, NM; Morriss, KM; Congreve, MS; Hawcock, AB; Marquess, D; Mordaunt, JE; Richards, SA; Ward, P 1,4-Benzodiazepin-2-one derived neurokinin-1 receptor antagonists Bioorg Med Chem Lett 7:2037-2042 (1997)    Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50346332
Synonyms:
2-Oxo-5-phenyl-1,2,3,5-tetrahydro-benzo[e][1,4]diazepine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide | CHEMBL293844 | N-(3,5-bis(trifluoromethyl)benzyl)-N-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-4(5H)-carboxamide
Type:
Small organic molecule
Emp. Form.:
C26H21F6N3O2
Mol. Mass.:
521.4543
SMILES:
CN(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)N1CC(=O)Nc2ccccc2C1c1ccccc1
Structure:
Search PDB for entries with ligand similarity: