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Target
Delta-type opioid receptor
Ligand
BDBM50290070
Substrate
n/a
Meas. Tech.
ChEBML_147161
Ki
1.8±n/a nM
Citation
 Pechulis, AD; Archer, S; Wentland, MP; Colasurdo, AM; Bidlack, JM Arylacetamide kappa-selective opioid ligands Bioorg Med Chem Lett 7:2271-2276 (1997)    Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50290070
Synonyms:
5-{3-[3-(1-{[2-(3,4-Dichloro-phenyl)-acetyl]-methyl-amino}-2-pyrrolidin-1-yl-ethyl)-phenyl]-thioureido}-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid | CHEMBL307919
Type:
Small organic molecule
Emp. Form.:
C42H36Cl2N4O6S
Mol. Mass.:
795.729
SMILES:
CN(C(CN1CCCC1)c1cccc(NC(=S)Nc2ccc(c(c2)C(O)=O)-c2c3ccc(O)cc3oc3cc(=O)ccc23)c1)C(=O)Cc1ccc(Cl)c(Cl)c1 |(8.59,-17.5,;8.59,-15.95,;9.92,-15.18,;11.25,-15.95,;12.59,-15.17,;12.75,-13.63,;14.26,-13.31,;15.03,-14.64,;14.01,-15.79,;9.92,-13.64,;8.59,-12.88,;8.58,-11.34,;9.92,-10.55,;11.25,-11.32,;12.59,-10.55,;12.59,-9.01,;11.25,-8.24,;13.92,-8.24,;13.92,-6.69,;12.59,-5.94,;12.58,-4.4,;13.92,-3.62,;15.25,-4.4,;15.25,-5.92,;16.8,-4.4,;17.57,-5.73,;17.57,-3.05,;13.92,-2.08,;12.59,-1.32,;11.27,-2.09,;9.94,-1.34,;9.92,.2,;8.59,.97,;11.25,.97,;12.58,.21,;13.91,1.01,;15.25,.23,;16.58,1,;17.89,.25,;19.23,1.02,;17.91,-1.29,;16.58,-2.07,;15.25,-1.29,;11.25,-12.87,;7.25,-15.18,;7.25,-13.64,;5.92,-15.95,;4.57,-15.18,;4.57,-13.64,;3.23,-12.87,;1.9,-13.64,;.57,-12.87,;1.9,-15.18,;.56,-15.95,;3.23,-15.95,)|
Structure:
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